On the Application Server, specifying IFS_HOME for the Windows Security Exclusions calmed the CPU usage of the "Antimalware Service Executable" process on the Application Server.

However, when I tried to log into IEE on the client PC, this time the CPU usage of the "Antimalware Service Executable" process on the client PC increased and IEE became very slow.

If you have any ideas to reduce the CPU usage of "Antimalware Service Executable", please let us know.

Add the Windows Defender exclusion list for Antimalware Service Executable. To access Windows Security Settings, press Windows key + I. To view it, simply use your mouse to scroll down and click Update & Security. Open-Update-and-Security
Then click Virus & Threat Protection Settings under Windows Security.
Click Add or Remove Exclusions under Exclusions.
Select Process > Add an Exclusion.
After entering MsMpEng.exe, click Add.

Dear @Santana 

Thank you for your kind support.

I set up the client PC according to your response.

However, when I logged into the IFS10 Update16 environment, as shown in the figure below, the CPU usage of the client PCs “Antimalware Service Executable” and “IFS Enterprise Explorer” were high and it took 4 minutes and 30 seconds for IEE to start and the situation did not improve.

In addition, I logged into the IFS10 Update 8 environment on the same client PC, and IEE started up in about 40 seconds.

If you have any other ideas that could improve the situation, we would appreciate your cooperation.

Best Regards,