It should be possible using Custom Events, but hard to say for sure with the limited information provided. 

hi

Thank you for the Response.

I have some Series of Sku’s which I want to restrict Returns on.
I checked  Master part Setting for the Sku;s, but I don't see any Check box or any options  to not allow Return for this.

I checked customer Order lines as well whether we can set return restriction when we are fulfilling orders so that Customer will know before hand that this Part is non returnable.

just checking my options how I can set this up ?